Construction of pcDNA/fimH Cassette as a DNA Vaccine Candidate Against Urinary Tract Infection and Evaluation of fimH Transcripts in COS7 Cell Line
نویسندگان
چکیده
منابع مشابه
rising cellular immune response after injection of pvax/iuta: a genetic dna cassette as candidate vaccine against urinary tract infection
background: uropathogenic escherichia coli (upec) are major bacterial agent of urinary tract infection (uti). this infection is more prevalent among women because approximately half of all women will experience a uti in their life-time and near a quarter of them will have a recurrent infection within 6–12 months. iuta protein has a major role during upec pathogenesis and consequently infection....
متن کاملRising Cellular Immune Response after Injection of pVax/iutA: A Genetic DNA Cassette as Candidate Vaccine against Urinary Tract Infection
BACKGROUND Uropathogenic Escherichia coli (UPEC) are major bacterial agent of Urinary Tract Infection (UTI). This infection is more prevalent among women because approximately half of all women will experience a UTI in their life-time and near a quarter of them will have a recurrent infection within 6-12 months. IutA protein has a major role during UPEC pathogenesis and consequently infection. ...
متن کاملCellular immunity survey against urinary tract infection using pVAX/fimH cassette with mammalian and wild type codon usage as a DNA vaccine
PURPOSE FimH (the adhesion fragment of type 1 fimbriae) is implicated in uropathogenic Escherichia coli (UPEC) attachment to epithelial cells through interaction with mannose. Recently, some studies have found that UPEC can thrive intracellularly causing recurrent urinary tract infection (UTI). Almost all vaccines have been designed to induce antibodies against UPEC. Yet, the humoral immune res...
متن کاملcloning and expression of fimh lectin domain as a candidate immunogen against urinary infection
background and objectives: urinary tract infection (uti) is one of the most common infections in human, and uropathogenic escherichia coli (upec) strains are the most common cause of uti. these strains colonize in bladder and cause cystitis, which could cause pyelonephritis by movement to the kidneys. since fimh protein has a very important role in colonization of upec strains and causing infec...
متن کاملConstruction of Mtb72F Plasmid as a DNA Vaccine Candidate for Mycobacterium tuberculosis
Background: With one-third of the world’s population infected, tuberculosis (TB) is one of the most common infectious diseases and a major public health problem, especially in developing countries. The efficacy of the BCG vaccine for controlling the disease in adults is poor. The development of an effective TB vaccine is a global objective. An effective tuberculosis vaccine should s...
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ژورنال
عنوان ژورنال: Research Journal of Microbiology
سال: 2009
ISSN: 1816-4935
DOI: 10.3923/jm.2009.75.81